The Skin-Care Products You Loved Most in 2025

A data-driven look at the formulas that earned your loyalty this year.

Leiana Foye

Published: Dec 10, 2025

We may earn commission from links on this page. Each product featured has been vetted and chosen by our editors.

At the end of every year, the editors at NewBeauty like to look back at the products and treatments that truly delivered—and made us feel our best. This time, we’re taking it a step further, spotlighting more than 15 skin-care staples you couldn’t get enough of. From do-it-all serums that target wrinkles, dark spots and sagging jawlines to award-winning devices raising the bar on at-home results, these are the products you agreed were the best of the best in 2025.

1 / 17

Hydrinity RetaXome Daily Retinal Hydrator ($145)

NB100 brand Hydrinity offers “injectable-grade hyaluronic acid–infused formulas.” The RetaXome Daily Retinal Hydrator uses a proprietary, precision-targeted biomimetic exosome technology (RetaXome), which, according to the brand, is 10 times more powerful and faster-acting than traditional retinol.

Featured in: 10 Products That Actually Firm and Tighten Sagging Skin, This New Retinal Serum Is Getting High Praise From Top Dermatologists

BUY NOW – $145

2 / 17

Laduora Lumeo SkinLift 4D Current™ Red Light Therapy Kit ($215)

Celebrity makeup artist Mélanie Inglessis let us in on the behind-the-scenes Emmys skin prep she used for Jenna Ortega’s strikingly chiseled and sculpted cheekbones: the Lumeo SkinLift 4D Current Red Light Therapy Kit. “It is a three-minute routine, and I see a difference straight away. It lifts and depuffs the skin, which is a must before a red carpet!”

Featured in: The Skin-Lifting Device That Helped Sculpt Jenna Ortega’s Cheekbones for the 2025 Emmys

BUY NOW – $215

3 / 17

SkinCeuticals Advanced RGN-6 Regenerative Cream ($195)

The first of two SkinCeuticals products on the best of 2025 list is Advanced RGN-6, a regenerative cream specifically formulated, clinically proven and physician tested to deliver skin-rejuvenation benefits similar to those of in-office laser treatments. That means you can expect reduced redness, acne marks, dark spots and wrinkles from just one serum, with continued use.

Featured in: SkinCeuticals Just Launched a Cream Inspired by the Effects of In-Office Laser Treatments

4 / 17

Augustinus Bader The Elixir ($550)

The Elixir is a unique anti-aging serum because its technology uses a delivery system to precisely deliver active ingredients to aging skin cells for visibly rejuvenated, healthier skin.

Featured in: Augustinus Bader’s New Elixir Is a 1-Stop Shop Anti-Aging Serum, Plastic Surgeons Name Their Favorite New Skin-Care Products of 2025

BUY NOW – $550

5 / 17

Dermelect Cosmeceuticals Smooth Upper Lip Professional Perioral Anti-Aging Treatment ($59)

This former NewBeauty Awards winner is a targeted at-home treatment that fills lip lines and smooths the delicate skin around the mouth.

Featured in: A Shopper in Their 60s Said Their Upper Lip Lines Look ‘Unnoticeable’ Thanks to This Treatment

6 / 17

The Ordinary GF 15% Serum ($16)

Growth factor serums can help to support collagen production and skin regeneration. The Ordinary’s version was a big hit among our readers this year, thanks to a formula with three types of growth factors and an affordable price.

Featured in: Shoppers Over 50 Rave This $16 Growth Factor Serum Firms Fine Lines

7 / 17

Dermalogica Phyto Nature Lifting Eye Cream ($118)

What sets this eye cream apart is that it’s safe to use on both the under-eye area and the upper eyelids to firm sagging.

Featured in: 11 Products That Lift and Firm Droopy Upper Eyelids, 9 Award-Winning Eye Creams for Smoother, Firmer and Revived Eyes

8 / 17

Avène Cicalfate+ Restorative Protective Cream ($26)

Cicalfate+ is a French pharmacy classic that soothes, restores and protects irritated or compromised skin. It can be used as a post-procedure skin care treatment, a daily moisturizer for dryness and irritation, an overnight mask and more.

Featured in: Hailey Bieber ‘Can’t Live Without’ This Under $30 Repair Cream, This Under-$30 Cream Has 45 Clinical Indications—Here’s Why Derms and Editors Can’t Stop Using It

9 / 17

La Roche-Posay Mela B3 Serum ($45)

For a non-hydroquinone dark spot corrector, our readers couldn’t buy La Roche-Posay’s Mela B3 Serum fast enough. Use it for all types of hyperpigmentation, including acne marks, sun exposure and age spots.

Featured in: Say Goodbye to Dark Spots for Good With These Serums, The Best Drugstore Serums That Actually Make a Difference

10 / 17

Mother Science Retinol Synergist ($96)

Utilizing malassezin and retinol together means even skin tone and dramatically softer fine lines and deeper wrinkles with no irritation.

Featured in: Shoppers Over 45 See a ‘Noticeable Glow’ Thanks to This Gentle Retinol, The Best Wrinkle Filler Products to Smooth Skin, Per Shoppers

BUY NOW – $96

11 / 17

DefenAge 8-in-1 Bioserum ($198)

Antioxidants, niacinamide, hyaluronic acid, collagen, anti-inflammatories, peptides, a retinol alternative and a DNA-repairing enzyme combine in one serum to smooth fine lines and texture and revive dull skin.

Featured in: This Anti-Aging Serum Combines 8 Serums in 1 and Readers Are Obsessed

BUY NOW – $198

12 / 17

Zo Skin Health Daily Sheer Broad-Spectrum SPF 50 ($70)

This dermatologist-recommended sunscreen packs a protective punch from UVA, UVB and HEV light while feeling light as air, making it especially beloved for sensitive skin types and post-procedure skin.

Featured in: 14 Derm- and Plastic Surgeon-Approved Post-Procedure Products You Can Buy on Amazon, What Should Be in Your Post-Procedure Survival Kit, According to Derms

BUY NOW – $70

13 / 17

ALASTIN C-Radical Defense Antioxidant Serum ($218)

A repeat NewBeauty Awards winner, Alastin’s vitamin C serum goes beyond brightening thanks to a formula with 15 potent antioxidants, including green tea and centella asiatica, to boost collagen, preserve elastin and refine skin texture.

Featured in: 22 Award-Winning Serums for Every Skin Concern, This Anti-Aging Vitamin C Serum Is a Favorite Among Readers Over 40

BUY NOW – $218

14 / 17

SkinMedica TNS Advanced+ Serum ($295)

SkinMedica’s TNS Advanced+ Serum contains two chambers, each dispensing a different product in a single pump. One chamber boasts growth factors; the other, antioxidants and peptides. Combined, the serums work to dramatically improve crepey skin and wrinkles.

Featured in: Dermatologists Weigh In on the ‘Botox in a Bottle’ Trend, ‘It Transformed My Face:’ Why Women Over 50 Are Loyal to This Serum

15 / 17

SkinCeuticals P-TIOX Anti-Wrinkle Peptide Serum ($150)

“P-TIOX features an advanced peptide complex tested on nine types of expression lines. It also contains a Glass Skin Complex with niacinamide and algae extract for instant smoothing,” reports our editor.

Featured in: 18 Award-Winning Products That Transform Mature Skin, The Best At-Home Products for Marionette Lines, According to Experts

16 / 17

NIRA Pro Laser ($649)

Use this device for just a few minutes a day at home to reduce the appearance of wrinkles and diminish hyperpigmentation.

Featured in: 11 Award-Winning Skin-Care Tools to Take Your Routine to the Next Level, This At-Home Laser Retails for $649—but You Can Try It for Just $45 a Month

BUY NOW – $649

17 / 17

SickScience Shapeshift V-Line Jaw-Defining Serum ($64)

The editor-loved ShapeShift serum “penetrates to work deep at the molecular level, helping sculpt the neckline like the most popular in-office procedures,” says our editors. “Lifting and tightening aside, it’s gentle on the skin and has a soothing gel consistency that sinks in effortlessly.”

Featured in: 31 Products for a Firmer, Tighter Jawline

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